Toxicological and mutagenic analysis of Artemisia dracunculus (tarragon) extract
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چکیده
منابع مشابه
Effective cytochrome P450 (CYP) inhibitors isolated from tarragon (Artemisia dracunculus).
Two effective cytochrome P450 (CYP) inhibitors were isolated from tarragon, Artemisia dracunculus. Their structures were spectroscopically identified as 2E,4E-undeca-2,4-diene-8,10-diynoic acid isobutylamide (1) and 2E,4E-undeca-2,4-diene-8,10-diynoic acid piperidide (2). Both compounds had dose-dependent inhibitory effects on CYP3A4 activity with IC50 values of 10.0 ± 1.3 µM for compound 1 and...
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Background: Coagulation activity of platelets plays an important role in thrombosis formation, Atherosclerotic plaque establishment and cardiovascular disorders. ASA are using as an anti platelet activity drug for patients with Coronary Artery Disease (CAD). Using of plant extraction as a complementary medicine for these patients (CAD) is mostly recommended by traditional medicine specialist. ...
متن کاملThe Electrophysiological Consequences of Artemisia dracunculus L. (Tarragon) Extract on Pentylenetetrazol-Induced Epilepti- form Activity in Snail Neurons
Objective: Plant extracts are of considerable interest because of their antiepileptic activities. However, the mechanisms of action are not clearly defined. Materials and Methods: Here, the effects of Artemisia dracunculus L. (tarragon) leaves extract on excitability and electrophysiological characteristics of snail neurones were investigated, using an intracellular recording technique. Results...
متن کاملThe effects of hydro-alcoholic extract of Artemisia dracunculus L. (Tarragon) on hematological parameters in mice
Introduction: Artemisia dracunculus L. (Tarragon) is one of the plants that uses as meal and remedy for a long time, and possesses many medicinal properties. In traditional medicine also has mentioned to its beneficial properties. A number of researches through in vitro and in vivo studies showed the pharmacological properties of this plant. This study was done for determining the effect of hyd...
متن کاملArtemisia dracunculus L. (tarragon): a critical review of its traditional use, chemical composition, pharmacology, and safety.
Artemisia dracunculus L. (tarragon) has a long history of use as a spice and remedy. Two well-described "cultivars" (Russian and French) are used widely and differ in ploidy level, morphology, and chemistry. Key biologically active secondary metabolites are essential oils (0.15-3.1%), coumarins (>1%), flavonoids, and phenolcarbonic acids. In vivo studies mainly in rodents, particularly from Ru...
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ژورنال
عنوان ژورنال: Food and Chemical Toxicology
سال: 2013
ISSN: 0278-6915
DOI: 10.1016/j.fct.2012.07.052